Mama maualuga 540737-29-9 Tofacitinib citrate mo le JAK Pathway Inhibitor

Fa'amatalaga Puupuu:

mama:≧99.0%

Tulaga lelei:Enterprise Standard po'o le mana'omia

Malosiaga:35Kgs/Masina

Soifua Fa'asao:Tolu Tausaga

Talosaga:Togafitiga fa'ama'i rūmatoid, gugu psoriatic, ankylosing spondylitis ma ulcerative colitis

Avanoa a le au:Au fa'atau fa'atau atu le poto masani fa'atasi ma a'oa'oga fa'apolofesa i fale gaosimea

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Fa'amatalaga Oloa

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Faailoga o oloa

Oloaigoa	Tofacitinib Citrate
Synonyms	(3R,4R)-1-(Cyanoacetyl)-4-methyl-N-methyl-N-1H-pyrrolo[2,3-d]pyrimidin-4-yl-3-piperidinamine 2-hydroxy-1,2,3 -propanetricarboxylate;CP 690500-10;CP 690550-10;(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-beta-oxo-1-piperidinepropanenitrile 2-Hydroxy-1,2,3-propanetricarboxylate
CAS Nu.	540737-29-9
Fa'aaliga	Pa'epa'e i le pa'epa'e pa'epa'e
Fuafua mole	C₁₆H₂₀N₆OC₆H₈O₇
Molecular Weight	504.50
Fa'atatauga	Vasega vaila'au po'o le fa'amoemoega o su'esu'ega
afifiina	E tusa ai ma lau talosaga
Teuina	Fa'asa'o i totonu o koneteina fufusi ma mama i se nofoaga malulu

Tofacitinib Citrate (CAS #540737-29-9)
MEA	TULAGA	I'UGA
Fa'aaliga	Pa'epa'e i le pa'epa'e pa'epa'e	Aveese le pauta pa'epa'e
Fa'ailoaga	HPLC;IR;HNMR	E usitaia
Solubility	Soluble i DMSO i le 100mg/ml, matua leaga soluble i ethanol, itiiti soluble i le vai ma isi.	E usitaia
Ma'imau ile Fa'amago	≤0.5%	0.12%
Toega ile mu	≤0.1%	0.05%
Metala mamafa	≤10ppm	E usitaia
Mea Fa'atatau	Diastereomer (RS+SR) ≤0.1% Le mama nofofua ≤0.15% Aofa'i le mama ≤1.0%	0.05% 0.14% 0.18%
Enantiomorphism Isomers	≤0.2%	E usitaia
Solvents totoe	Ethanol ≤5000ppm Methanol ≤3000ppm Toluene ≤890ppm	E usitaia
Citrate Content	36.2%~40%	37.8%
Mama	≥99.0%	99.38%
Su'ega	60.68%~63.16% o Tofacitinib INN 98% ~ 102% o Tofacitinib Citrate INN	62.04% 99.12%
Fa'ai'uga: Fa'amalie

Fa'amatalaga a Kamupani

√ Ole poto masani ole pulega ile falegaosimea ma tagata tomai fa'atekinisi;
√ O le tulaga lelei e masani lava o la tatou iloiloga maualuga, faiga QC Strict;
√ 11 tausaga le poto masani i le auina atu i fafo au faʻatau;
√ fale su'esu'e Tuto'atasi;
√ Lua fa'aa'oa'oga a le GMP umi saini;
√ Mauoa o punaoa o le tele o falegaosimea fa'aletonu mo galuega fa'apitoa;
√ Aufaigaluega Maualuga Maualuga ma ala faifai pea.
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